An NADP+ enzyme catalyzing the dehydrogenation of d-glucose 6-phosphate to 6-phospho-d-glucono-δ-lactone, this reaction initiating the pentose shunt. A deficiency of this enzyme can lead to severe hemolytic anemia and favism. A deficiency of the leukocyte enzyme prevents neutrophils expressing respiratory burst. SYN: Robison ester dehydrogenase, Zwischenferment.
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glucose-6-phosphate dehydrogenase n an enzyme found esp. in red blood cells that dehydrogenates glucose-6-phosphate in a glucose degradation pathway alternative to the Krebs cycle
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(G6PD) glu·cose-6-phos·phate de·hy·dro·gen·ase (G6PD) (glooґkōs fosґfāt de-hiґdro-jən-ās) [EC 1.1.1.49] an enzyme of the oxidoreductase class that catalyzes the oxidation of glucose-6-phosphate to a lactone, reducing NADP+ to NADPH. The reaction is the first step in the pentose phosphate pathway of glucose metabolism. Genetic deficiency of the enzyme causes severe hemolytic crises in affected individuals. In EC nomenclature, called glucose-6-phosphate 1-dehydrogenase.Medical dictionary. 2011.