A rare dermatosis in which there is a thickening of the stratum corneum with an annular keratotic rim or cornoid lamella surrounding progressive centrifugal atrophy; cutaneous carcinoma has been reported to arise in the lesions. SYN: Mibelli disease. [G. poros, pore, + keratosis]
- actinic p. a lesion that occurs on exposed areas of extremities primarily; bears a resemblance to actinic keratosis, but the histologic features are those of p..
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po·ro·ker·a·to·sis -.ker-ə-'tō-səs n any of several uncommon inherited skin disorders characterized by hypertrophy of the stratum corneum
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po·ro·ker·a·to·sis (por″o-ker″ə-toґsis) [poro-2 + keratosis] any of several chronic, progressive disorders of keratinization, seen most often in light-skinned persons. The characteristic lesion is round and craterlike with an atrophic center and an elevated, thick, keratotic border formed by a cornoid lamella; lesions may enlarge into circinate, serpiginous, or gyrate forms. Lesions can be premalignant, progressing to basal cell carcinoma or squamous cell carcinoma. It is sometimes inherited as an autosomal dominant disorder, but most cases are sporadic, and a number of factors, including ultraviolet exposure, infection, and immunosuppression, may be involved in its pathogenesis. porokeratotic adjMedical dictionary. 2011.