1. Denoting the anterior portion of the frontal lobe of the cerebrum. 2. Denoting the granular frontal cortex rostral to the premotor area.
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pre·fron·tal .prē-'frənt-əl adj
1) situated or occurring anterior to a frontal structure <a \prefrontal bone>
2) of, relating to, or constituting the prefrontal lobe or prefrontal cortex of the brain
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pre·fron·tal (pre-fronґtəl) situated in the anterior part of the frontal lobe or region.Medical dictionary. 2011.