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Hodg·kin's disease 'häj-kənz- n a neoplastic disease that is characterized by progressive enlargement of lymph nodes, spleen, and liver and by progressive anemia

Hodgkin Thomas (1798-1866)

British physician. Hodgkin made important contributions in pathology, including a treatise on the anatomy of diseased tissue that spurred the study of tissue pathology in Great Britain. He is known for his description of aortic regurgitation in 1829 and of Hodgkin's disease in 1832. The latter disease was named in his honor in 1865 by fellow British physician Sir Samuel Wilks (1824-1911).

a malignant disease of lymphatic tissue - a form of lymphoma - usually characterized by painless enlargement of one or more groups of lymph nodes in the neck, axillae (armpits), groin, chest, or abdomen; the spleen, liver, bone marrow, and bones may also be involved. Apart from the enlarging nodes, there may also be weight loss, fever, profuse sweating at night, and itching (known as B symptoms). Hodgkin's disease is distinguished from other forms of lymphoma by the presence of large binucleate cells (Sternberg-Reed cells) in the affected lymph nodes. Treatment depends on the extent of disease and may include surgery, radiotherapy, drug therapy, or a combination of these. Drugs used in the treatment of the disease include nitrogen mustard, vincristine, procarbazine, prednisolone, chlorambucil, and vinblastine. Many patients can be cured; in the early stages of the disease this may be in the order of 85% or more.