Akademik

Pag·et's disease .paj-əts- n

1) a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola

2) a chronic disease of bones characterized by their great enlargement and rarefaction with bowing of the long bones and deformation of the flat bones called also osteitis deformans, osteodystrophia deformans

1. a chronic disease of bones, occurring in the elderly and most frequently affecting the skull, backbone, pelvis, and long bones. Affected bones become thickened and their structure disorganized: X-rays reveal patchy sclerosis. There are often no symptoms, but pain, deformity, and fracture can occur; when the skull is affected, blindness and deafness can occur due to nerve compression. There is a very small (1%) risk of malignant change (osteosarcoma). Treatment is with bisphosphonates or calcitonin. Medical name: osteitis deformans.

2. a malignant condition of the nipple, resembling eczema in appearance, associated with underlying infiltrating cancer of the breast. See also breast cancer.

3. an uncommon condition of the vulva characterized by an epithelial lesion that histologically resembles the lesion of Paget's disease of the nipple. It may be associated with locally invasive adenocarcinoma of the surrounding skin, as well as tumours at other sites.