1. The functional and morphologic fluctuation of cells in response to changing environmental conditions. 2. Systematic variation in a characteristic ( e.g., frequency, amplitude) of a sustained oscillation to code additional information. 3. A change in the kinetics of an enzyme or metabolic pathway. 4. The regulation of the rate of translation of mRNA by a modulating codon. [L. modulor, to measure off properly]
- biochemical m. term describing the m. (either enhancement of activity or reduction of toxicity) of a chemotherapeutic agent by another agent, which may or may not have antineoplastic activity of its own.
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mod·u·la·tion .mäj-ə-'lā-shən n
1) the act or process of modulating
2) a reversible change in histological structure due to physiological factors
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mod·u·la·tion (mod″u-laґshən) [L. modulare to measure] 1. the act of tempering or toning down. 2. alteration in a cell in response to environmental stimuli. 3. embryologic induction in a specific region.Medical dictionary. 2011.